| 生长激素促分泌素受体(GHS-R)的发现及影响 |
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| 引用本文： | 黄希贵,焦保卫,王德寿.生长激素促分泌素受体(GHS-R)的发现及影响[J].动物学杂志,2004,39(2):84-88. |
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| 作者姓名： | 黄希贵 焦保卫 王德寿 |
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| 作者单位： | 西南师范大学生命科学学院,重庆市水产科学重点实验室,重庆,400715 |
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| 摘 要： | 生长激素的分泌不仅受到GHRH、SRIF的调节 ,还受到GHS R及其配体GHS的作用。本文综述了GHS R的发现背景、结构特点以及生理功能 ,讨论了GHS R促GH分泌的分子机制及其对多种组织器官可能影响 ,同时还探讨了除Ia和Ib亚型外还存在其它GHS R亚型的可能性。
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| 关 键 词： | 生长激素促分泌素受体 生长激素促分泌素 Ghrelin 生长激素 |
| 文章编号： | 0250-3263(2004)02-84-05 |
GHS-R:A Novelly Identified GH-secreting Protein |
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| HUANG Xi,Gui,JIAO Bao,Wei,WAND De,Shou.GHS-R:A Novelly Identified GH-secreting Protein[J].Chinese Journal of Zoology,2004,39(2):84-88. |
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| Authors: | HUANG Xi Gui JIAO Bao Wei WAND De Shou |
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| Abstract: | GHS R is a newly identified protein from human and porcine hypothalamus and pituitary, which mainly acts as promotion factor of GH secretion in conjunction with GHS. The intensive results imply that GHS R not only regulates the secretion of GH, but also has profound effect on various tissues and organs. The present review delineates the profile of GHS R in terms of its identification background, structural characters as well as its biological functions. Also, this review discusses the possible existence of other subtypes besides GHS R Ia and Ib and tries to elicit the hypothesis of the existence of GHS R inhibitors. |
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| Keywords: | Growth hormone secretagogue receptor Growth hormone secretagogue Ghrelin Growth hormone |
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