| 生态毒理基因组学和生态毒理蛋白质组学研究进展 |
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| 引用本文： | 戴家银,王建设.生态毒理基因组学和生态毒理蛋白质组学研究进展[J].生态学报,2006,26(3):930-934. |
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| 作者姓名： | 戴家银 王建设 |
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| 作者单位： | 中国科学院动物研究所,北京,100080 |
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| 基金项目： | 中国科学院知识创新工程项目 |
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| 摘 要： | 将基因组学和蛋白质组学知识整合到生态毒理学中形成了生态毒理基因组学和生态毒理蛋白质组学.通过生态毒理基因组学和生态毒理蛋白质组学的研究能够在基因组和蛋白质组水平更深入理解毒物的作用机制,寻找更敏感、有效的生物标记物,形成潜在的强有力的生态风险评价工具.介绍了生态毒理基因组学和生态毒理蛋白质组学的研究进展,以及DNA芯片技术和2D-凝胶电泳技术在持久性有毒污染物的生态毒理学研究中的应用.
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| 关 键 词： | 生态毒理基因组学 生态毒理蛋白质组学 DNA芯片技术 2D-凝胶电泳 持久性有机污染物 |
| 文章编号： | 1000-0933（2006）03-0930-05 |
| 收稿时间： | 2005-08-30 |
| 修稿时间： | 2005-08-302005-12-05 |
Progress in ecotoxicogenomics and ecotoxicoproteomics |
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| DAI Jiayin and WANG Jianshe.Progress in ecotoxicogenomics and ecotoxicoproteomics[J].Acta Ecologica Sinica,2006,26(3):930-934. |
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| Authors: | DAI Jiayin and WANG Jianshe |
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| Institution: | Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | Ecotoxicogenomics and ecotoxicoproteomics are integration of genomics and proteomics into ecotoxicology. Ecotoxicogenomics is defined as the study of gene and protein expression in non-target organisms that is important in responses to environmental toxicant exposures. Ecotoxicogenomic tools may provide us with a better mechanistic understanding of ecotoxicology, and they are likely to provide a vital role in ecological risk assessment. Progress in ecotoxicogenomics and ecotoxicoproteomics are discussed in this paper. DNA gene chip and 2D-gel usually used in ecotoxicogenomics and ecotoxicoproteomics are also expounded by examples. |
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| Keywords: | ecotoxicogenomics ecotoxicoproteomics DNA microarray 2D-gel persistent organic pollutants |
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