N-(1-Carboxyethyl)alanine (alanopine), a new non-sugar component of lipopolysaccharides of Providencia and Proteus |
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| Authors: | Nina A Kocharova Olga G Ovchinnikova Andrei V Perepelov Alexander S Shashkov Yuriy A Knirel |
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| Institution: | N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation |
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| Abstract: | O-Polysaccharides were released by mild acid degradation of lipopolysaccharides of Providencia alcalifaciens O35 and Proteus vulgaris O76 and were studied by 1D and 2D 1H and 13C NMR spectroscopies, including HMBC and NOESY (ROESY) experiments. Both polysaccharides were found to contain N-(1-carboxyethyl)alanine (alanopine) that is N-linked to 4-amino-4,6-dideoxyglucose. Analysis of published data Vinogradov, E.; Perry, M. B. Eur. J. Biochem.2000, 267, 2439-2446] shows that alanopine is present also on the same sugar in the lipopolysaccharide core of Proteus mirabilis O6 and O57. |
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| Keywords: | Providencia alcalifaciens Proteus vulgaris O-Antigen Lipopolysaccharide Alanopine 4-Amino-4 6-dideoxyglucose |
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