Towards a modular synthesis of well-defined chitooligosaccharides: synthesis of the four chitodisaccharides |
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| Authors: | Nadine Barroca-Aubry |
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| Institution: | Laboratoire des Matériaux Polymères et des Biomatériaux, Ingénierie des Matériaux Polymères, UMR CNRS 5223, Université Lyon 1, Domaine scientifique de La Doua, Bât. ISTIL, 15 Bd Latarjet, F-69622 Villeurbanne Cedex, France |
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| Abstract: | The total chemical synthesis of the four well-defined chitodisaccharides is described using N-trichloroacetyl (TCA) and N-benzyloxycarbonyl (Z) as C-2 protecting groups for acetamido and free amino groups, respectively. The synthesis is carried out according to a strategy that paves way to the elaboration of various homo- and hetero-chitooligosaccharides, with perfect control of the number and the position of GlcN and GlcNAc units along the oligomer chain. |
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| Keywords: | Chitooligosaccharides Chitodisaccharides Chitosan oligomers Chitin oligomers Chemical synthesis |
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