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Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin |
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| Authors: | Blériot Yves Gretzke Dirk Krülle Thomas M Butters Terry D Dwek Raymond A Nash Robert J Asano Naoki Fleet George W J |
| Institution: | Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. yves.bleriot@chimie.ens.fr |
| Abstract: | 1,6-Dideoxygalactostatin, the mirror image of 1-deoxy-L-fuconojirimycin, was efficiently prepared from 2,3-O-isopropylidene-L-lyxonolactone in four steps and evaluated as a glycosidase inhibitor. |
| Keywords: | Galactostatin Glycosidase inhibitor 1-Deoxyfuconojirimycin Iminosugar Mirror image |
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