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Synthesis of 5-deoxy-5-fluorosporaricin A
Authors:Takahiro Torii  Tsutomu Tsuchiya  Sumio Umezawa
Institution:Institute of Bioorganic Chemistry, 1614 Ida, Nakahara-ku, Kawasaki 211 Japan
Abstract:The structures of the O-specific side-chains in the lipopolysaccharides of Salmonella greenside, group Z, and Salmonella adelaide, group O, have been investigated. The former proved to be identical with that of Escherichia coli O 55. The latter, which was more extensively studied, was composed of repeating units having the structure
/></figure> in which Col is colitose (3,6-dideoxy-l-<em>xylo</em>-hexose). This was also shown to be the biological repeating-unit. The same structure has been proposed for the O-antigen of <em>E. coli</em> O 111. The biological repeating-unit for the <em>S. greenside</em> O-antigen was also defined. The structural studies also confirmed that both lipopolysaccharides contain the hexose region typical for the <em>Salmonella</em> core.</td>
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