Searching the human genome database for novel relaxin- and insulin-like peptides |
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Authors: | Bathgate Ross AD Scott Daniel J Chung Sean WL Ellyard Daniel Garreffa Amanda M Tregear Geoffrey W |
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Institution: | (1) Howard Florey Institute, University of Melbourne, 3010, Victoria, Australia |
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Abstract: | Summary In recent times, new members of the insulin/relaxin peptide superfamily have been identified by both differential cloning
strategies as well as bioinformatic searching of the EST databases. We have used the public and Celera Genomics databases
to search for novel members of this peptide family. No new members of the insulin/relaxin family were identified although
the human (H3) and mouse (M3) relaxin 3 genes that we recently discovered in the Celera Genomics database were identified
in the public database. We were able to confirm that there are no mouse equivalents of human INSL-4 or human gene 1 relaxin.
Hence, as the two human relaxin genes (H1 and H2) are localized together with INSL6 and INSL4 on chromosome 9 it is probable
that INSL4 and H1 relaxin are the result of a gene duplication which did not occur in non-primates. The discovery of a full
relaxin 3 sequences in a new Zebrafish brain EST library, which retains a high homology in both A and B chain peptide sequence
with the H3 peptide, indicate that this novel peptide has important conserved functions. |
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Keywords: | human genome database insulin-like INSL3 INSL4 INSL5 INSL6 relaxin |
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