Synthesis of Neoglycopeptides via Click Chemistry |
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Authors: | Nicole Miller Geoffrey M Williams Margaret A Brimble |
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Institution: | (1) Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand; |
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Abstract: | Novel chemical methods to access homogeneous samples of glycopeptides and glycoproteins and their mimetics, so-called neoglycopeptides
and neoglycoproteins, have developed rapidly in recent years owing to an increased need to investigate both their roles in
molecular biology and their potential as therapeutic agents. This article summarizes the application of the copper-catalyzed
azide-alkyne cycloaddition for the chemical synthesis of neoglycopeptides and neoglycoproteins. |
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Keywords: | |
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