Elasticity and Biochemistry of Growth Relate Replication Rate to Cell Length and Cross-link Density in Rod-Shaped Bacteria |
| |
Authors: | Akeisha MT Belgrave Charles W Wolgemuth |
| |
Institution: | † University of Connecticut Health Center, Department of Cell Biology and Center for Cell Analysis and Modeling, Farmington, Connecticut;‡ University of Arizona, Departments of Physics and Molecular and Cellular Biology, Tucson, Arizona |
| |
Abstract: | In rod-shaped bacteria, cell morphology is correlated with the replication rate. For a given species, cells that replicate faster are longer and have less cross-linked cell walls. Here, we propose a simple mechanochemical model that explains the dependence of cell length and cross-linking on the replication rate. Our model shows good agreement with existing experimental data and provides further evidence that cell wall synthesis is mediated by multienzyme complexes; however, our results suggest that these synthesis complexes only mediate glycan insertion and cross-link severing, whereas recross-linking is performed independently. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|