Anthranilic Acid,as a Fruiting Body Inducing Substance in Favolus arcularius,from a Strain TA 7 of Actinomycetes |
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| Authors: | Sawao Murao Hideo Hayashi Naoki Tarui |
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| Institution: | Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Sakai 591, Japan |
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| Abstract: | The stereochemical inversion of (R)-5-hydroxymethyl-3-tert-butyl-2-oxazolidinone (la) or (R)-5-hydroxymethyl-3-isopropyl-2-oxazolidinone (lb) to the corresponding (S)-isomer was accomplished via a key intermediate, (R)-3-N-ethoxycarbonyl-N-tert-butylamino-l,2-epoxypropane (5a) or (R)-3-N-ethoxycarbonyl-N-isopropylamino-l,2-epoxypropane (5b), in a high enantiomeric excess. (S)-la (99%e.e.) or (S)-lb (91%e.e.) was thus obtained from the respective (R)-isomer (la; 99%e.e., lb; 95%e.e.). |
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