Protective effects of Platycodi radix on alcohol-induced fatty liver |
| |
Authors: | Kim Hye Kyung Kim Dong-Sub Cho Hong-Yon |
| |
Institution: | Department of Food and Biotechnology, Hanseo University, Korea. |
| |
Abstract: | The protective effects of Platycodi radix (PR), the root of Platycodon grandiflorum A. DC, on alcohol-induced fatty liver and possible mechanisms involved in this protection were investigated in rats. Administration of PR significantly prevented alcohol-induced elevation of serum and liver lipids. Furthermore, PR treatment normalized hepatic liver fatty acid binding protein (L-FABP) expression and cytochrome P450 2E1 (CYP2E1) activity in alcohol-treated rats. These results suggest that inhibition of CYP2E1 and regulation of L-FABP by PR play an important role in alcohol-induced hepatoprotection. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|