An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3 |
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| Authors: | Jing-Ming Yang Ya-Yue Liu Wen-Cong Yang Xiao-Xiang Ma Ying-Ying Nie Evgenia Glukhov |
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| Institution: | 1. College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China;2. Marine Medicine Research and Development Center, Shenzhen Institute of Guangdong Ocean University , Shenzhen, China;3. College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China;4. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California , San Diego, CA, USA |
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| Abstract: | ABSTRACT A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2–6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4?-hydroxy-6,7-dimethoxyisoflavone), and 5–7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. |
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| Keywords: | Soybean Aspergillus terreus marine fungus isoflavone anti-inflammation |
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