Anti-inflammatory effect of Euphorbia supina extract in dextran sulfate sodium-induced colitis mice |
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Authors: | Ji-Yun Cha Yong-Deok Jeon Mingjie Xin Do-Kuk Kim Hoon-Yeon Lee Bo-Ram Kim |
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Institution: | 1. Department of Oriental Pharmacy, College of Pharmacy, Wonkwang Oriental Medicine Research Institute, Wonkwang University, Iksan, Jeollabuk-do, Republic of Korea;2. Department of Oriental Medicine Resources, Chonbuk National University, Iksan, Jeollabuk-do, Republic of Korea;3. EastHill Co., Gwonseon-gu, Suwon, Gyoenggi-do, Republic of Korea;4. National Institute of Horticultural and Herbal Science, RDA, Jeonju, Jeollabuk-do, Republic of Korea |
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Abstract: | The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days. Twenty mg/kg of ES administration regulated body weight decrease, recovered colon length shortening, and increased disease activity index score and myeloperoxidase level in DSS-induced colitis. Histological features showed that 20 mg/kg of ES administration suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Furthermore, ES suppressed the expressions of COX-2, iNOS, NF-kB, IkBα, pIkBα in colon tissue. These findings demonstrated a possible effect of amelioration of ulcerative colitis and could be clinically applied. |
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Keywords: | Euphorbia supina (ES) dextran sulfate sodium colitis myeloperoxidase iNOS COX-2 |
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