Natural product discovery through microbial genome mining |
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| Institution: | 1. Biotechnology Research Center, Southwest University, Chongqing 400716, China;2. Academy of Agricultural Sciences, Southwest University, Chongqing 400716, China;1. Molecular Engineering Lab, Institute of Bioengineering and Nanotechnology, A*STAR, 138669, Singapore;2. Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, 35053, Taiwan;3. Molecular Engineering Lab, Institute of Molecular and Cell Biology, A*STAR, 138669, Singapore;4. Singapore Institute of Food and Biotechology Innovation, A*STAR, 138669, Singapore;1. Center for Marine Biotechnology & Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA;2. Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA;3. Skaggs School of Pharmacy and Pharmaceutical Sciences, Departments of Pharmacology, Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA;1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, USA;2. Center for Microbiome Innovation, University of California, San Diego, USA;1. Laboratory of Genetically Encoded Small Molecules, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA;2. Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA |
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| Abstract: | The advent of the genomic era has opened up enormous possibilities for the discovery of new natural products. Also known as specialized metabolites, these compounds produced by bacteria, fungi, and plants have long been sought for their bioactive properties. Innovations in both DNA sequencing technologies and bioinformatics now allow the wealth of sequence data to be mined at both the genome and metagenome levels for new specialized metabolites. However, a key problem that remains is rapidly and efficiently linking these identified genes to their corresponding compounds. Within this review, we provide specific examples of studies that have used the power of genomic or metagenomic data to overcome these problems and identify new small molecules and their biosynthetic pathways. |
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| Keywords: | Genomics Specialized metabolite Metagenomics Genome mining |
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