Metal complexes as optical probes for DNA sensing and imaging |
| |
| Affiliation: | 1. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian, 116024, China;2. Gold Catalysis Research Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, PR China;1. Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, 999078, China;2. Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong SAR, 999077, China |
| |
| Abstract: | Transition and lanthanide metal complexes have rich photophysical properties that can be used for cellular imaging, biosensing and phototherapy. One of the applications of such luminescent compounds is the detection and visualisation of nucleic acids. In this brief review, we survey the recent literature on the use of luminescent metal complexes (including ReI, RuII, OsII, IrIII, PtII, EuIII and TbIII) as DNA optical probes, including examples of compounds that bind selectively to non-duplex DNA topologies such as quadruplex, i-motif and DNA mismatches. We discuss the applications of metal-based luminescent complexes in cellular imaging, including time-resolved microscopy and super-resolution techniques. Their applications in biosensing and phototherapy are briefly mentioned in the relevant sections. |
| |
| Keywords: | Optical probes DNA Phototherapy Cellular imaging Transition metals Lanthanides |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
