Expression of Bcl-2 and p53 at the fetal-maternal interface of rhesus monkey |
| |
Authors: | Peng?Wei Xuan?Jin Xue-Sen?Zhang Zhao-Yuan?Hu Chun-Sheng?Han Email author" target="_blank">Yi-Xun?LiuEmail author |
| |
Institution: | (1) State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100080, China |
| |
Abstract: | To study the apoptosis and its mechanism at the fetal-maternal interface of early gestation, localization of apoptotic cells
in the implantation sites of the rhesus monkey on day 17, 19, 28 and 34 of pregnancy were first examine by using the TUNEL
technique. The expression of Ki67, a molecular marker of proliferating cells, and two apoptotic proteins, B cell lymphoma/leukaemia-2
(Bcl-2) and P53, were then studied by immunohistochemistry. Apoptotic nuclei were observed mainly in the syncytiotrophoblast.
Ki67 was confined almost exclusively to cytotrophoblasts. The localization of Bcl-2 protein follows that of the apoptotic
nuclei and its expression level increased as the development of the placenta progressed on. P53 was detected to some extent
in cytotrophoblasts and syncytiotrophoblast covering the basal feet of the anchoring villi during the late stage of placentation.
Based on these observations, it might be suggested that Bcl-2 could be possible to play an interesting role in limiting degree
of nuclear degradation and sustaining cell suvival in the multi-nucleated syncytiotrophoblast cells during early pregnancy,
and P53 could also be essential in regulating the trophoblastic homeostasis by controlling its proliferation or apoptosis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|