Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat |
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Authors: | Marcelo Filonzi Laís C Cardoso Maristela T Pimenta Daniel BC Queiróz Maria CW Avellar Catarina S Porto and Maria FM Lazari |
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Institution: | (1) Department of Pharmacology, Section of Experimental Endocrinology, Federal University of S?o Paulo, Rua Tr?s de Maio, 100, CEP 04044-020 S?o Paulo, SP, Brazil |
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Abstract: | Background Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1, previously known as LGR7. In humans relaxin can
also activate, but with lower affinity, the closely related receptor for the insulin-like peptide from Leydig cells, RXFP2,
previously known as LGR8. The lack of relaxin impairs male fertility but the precise distribution and the function of relaxin
receptors in the male reproductive tract is not known. We investigated the distribution of Rxfp1 and Rxfp2 in the reproductive
tract of the male rat and the function of relaxin in the vas deferens, a tissue with high expression of both receptors. |
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