Altered placental expression of PAPPA2 does not affect birth weight in mice |
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Authors: | Pamela K Wagner Julian K Christians |
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Institution: | (1) Simon Fraser University, Biological Sciences, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada |
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Abstract: | Background Pregnancy-associated plasma protein A2 (PAPPA2) is an insulin-like growth factor binding protein (IGFBP) protease expressed
in the placenta and upregulated in pregnancies complicated by pre-eclampsia. The mechanism linking PAPPA2 expression and pre-eclampsia
and the consequences of altered PAPPA2 expression remain unknown. We previously identified PAPPA2 as a candidate gene for
a quantitative trait locus (QTL) affecting growth in mice and in the present study examined whether this QTL affects placental
PAPPA2 expression and, in turn, placental or embryonic growth. |
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