Ultrastructure of human spleen in transmission and scanning electron microscope |
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Authors: | tefan Polák Paulína Gálfiová and Ivan Varga |
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Institution: | (1) Department of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, SK-81108 Bratislava, Slovakia |
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Abstract: | Despite new information concerning functional morphology of spleen, there are still some inaccuracies mostly regarding the
spleen blood circulation. Billroth’s (splenic) cords are formed from three-dimensional network of fibroblastic reticular cells
located among branched sinuses. Results from our study using scanning electron microscopy confirm an intimate contact between
adjacent reticular cells and erythrocytes. Arterial terminals can be observed in the Billroth’s cords. The wall of sinuses
reminds a sieve and it is lined with a special type of endothelium. In electron microscope, endothelial cells look like rods
oriented parallel to the longitudinal axis of sinuses. Based on our observations fibroblastic reticular cells change to fixed
phagocytes under no circumstances, hence they do not participate in phagocytosis. They may have a recognition function for
cells circulating around them. According to our opinion, the open and the closed blood circulation are present in the human
spleen simultaneously. Blood flowing in the closed circulation can help “absorption” of extra-vascular liquid and the blood
elements into the vascular lumen. Due to sporadic occurrence of smooth muscle cells in the capsule and trabeculae, we assume
that human spleen is not a blood reservoir, unlike the spleen in some other animals. |
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Keywords: | human spleen ultrastructure |
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