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Inhibition of platelet phosphatidylinositol synthetase by an analog of CDP-diacylglycerol |
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| Authors: | L A Vargas X M Li A F Rosenthal |
| Abstract: | Unpublished portions of the synthesis of a phosphinate-phosphonate diether analog of CDPdiacylglycerol are reported. The liponucleotide analog was found to be a very powerful inhibitor of platelet PI synthetase; kinetic data suggest a competitive inhibition mechanism. The structural specificity of CDPdiacylglycerol for liponucleotide-mediated biosynthetic reactions is discussed. |
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