Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake |
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Authors: | Trigatti B L Rigotti A Braun A |
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Institution: | Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. trigatt@mcmaster.ca |
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Abstract: | High-density lipoproteins (HDL) play an important role in protection against atherosclerosis by mediating reverse cholesterol transport - the transport of excess cholesterol from peripheral tissues to the liver for disposal. SR-BI is a cell surface receptor for HDL and other lipoproteins (LDL and VLDL) and mediates the selective uptake of lipoprotein cholesterol by cells. Overexpression or genetic ablation of SR-BI in mice revealed that it plays an important role in HDL metabolism and reverse cholesterol transport and protects against atherosclerosis in mouse models of the disease. If it plays a similar role in humans then it may be an attractive target for therapeutic intervention. We will review some of the recent advances in the understanding of SR-BI's physiological role and cellular function in lipoprotein metabolism. |
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