Therapeutic modulation of V Set and Ig domain-containing 4 (VSIG4) signaling in immune and inflammatory diseases |
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| Institution: | 1. Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China;2. Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China;1. Pediatrics, Nationwide Children''s Hospital, Columbus, Ohio, USA;2. Center for Regenerative Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA;3. Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA;4. Center for Cellular Immunotherapies, Philadelphia, Pennsylvania, USA;5. Steno Diabetes Center Copenhagen, Copenhagen, Denmark;6. Faculty of Medicine and Health (FML), FML Medical Research Institutes, University of Sydney, Sydney Australia;7. Obsidian Therapeutics, Cambridge, Massachusetts, USA;1. Center for Cellular Engineering, Department of Transfusion Medicine and Center for Cellular Engineering, National Instates of Health Clinical Center, Bethesda, Maryland, USA;2. Department of Medicine (Hematology Division), University of Washington/Fred Hutchinson Cancer Center, Seattle, Washington, USA;1. Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China;2. Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China;3. Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China;4. Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China;5. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;6. Department of Respiratory Medicine, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China;7. Department of Hepatobiliary Surgery, Chinese People''s Liberation Army General Hospital, Chinese People''s Liberation Army Medical College, Beijing, China;8. Institute of Hepatobiliary Surgery, Chinese People''s Liberation Army General Hospital, Chinese People''s Liberation Army Medical College, Beijing, China;9. Department of Pathology, Xiangya Hospital, Central South University, Changsha, China;10. Department of Infectious Disease, People''s Hospital of Liuyang City, Liuyang, China;11. Institute of Basic Medicine Science, Chinese People''s Liberation Army General Hospital, Chinese People''s Liberation Army Medical College, Beijing, China;12. Center of Pulmonary and Critical Care Medicine, Chinese People''s Liberation Army General Hospital, Chinese People''s Liberation Army Medical College, Beijing, China;1. Pediatric Hematology-Oncology Fellow, Memorial Sloan Kettering Cancer Center, and Department of Pediatrics, Weill Cornell Medical College of Cornell University, New York, New York, USA;2. Center for Cancer and Immunology Research, CETI, Children''s National Hospital, Washington, District of Columbia, USA;3. Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, California, USA;4. Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children''s Research Hospital, Memphis, Tennessee, USA;5. Pediatric Blood and Marrow Transplantation Division and Pele Pequeno Principe Research Institute, Hospital Pequeno Principe, Curitiba, Brazil;6. Universite de Montreal and Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada;7. Bone Marrow Failure and MDS Program, John Hopkins Medicine Baltimore, Maryland, USA;8. CRISPR Therapeutics Cambridge, Massachusetts, USA;9. Stem Cell Transplantation and Cellular Therapies, Memorial Sloan Kettering Cancer Center, New York, New York, USA;10. Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Redwood City, California, USA;11. Department of Haematology, Fiona Stanley Hospital, Perth, Western Australia, Australia;12. IRCCS Ospedale San Raffaele, Segrate, Milan, Italy;13. Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, USA;14. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK;15. Stem Cell Transplantation and Cellular Therapies, Memorial Sloan Kettering Cancer Center, and Department of Pediatrics, Weill Cornell Medical College of Cornell University, New York, New York, USA;16. Dana-Farber/Boston Children''s Cancer and Blood Disorders Center, Boston, Massachusetts USA |
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| Abstract: | Inflammation is the result of acute and chronic stresses, caused by emotional or physical trauma, or nutritional or environmental pollutants, and brings serious harm to human life and health. As an important cellular component of the innate immune barrier, the macrophage plays a key role in maintaining tissue homeostasis and promoting tissue repair by controlling infection and resolving inflammation. Several studies suggest that V Set and Ig domain-containing 4 is specifically expressed in tissue macrophages and is associated with a variety of inflammatory diseases. In this paper, we mainly summarize the recent research on V Set and Ig domain-containing 4 structures, functions, function and roles in acute and chronic inflammatory diseases, and provide a novel therapeutic avenue for the treatment of inflammatory diseases, including nervous system, urinary, respiratory and metabolic diseases. |
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