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Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter |
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| Authors: | Stephan Kellnberger Georg Wissmeyer Mazen Albaghdadi Zhonglie Piao Wenzhu Li Adam Mauskapf Philipp Rauschendorfer Guillermo J Tearney Vasilis Ntziachristos Farouc A Jaffer |
| Institution: | 1. Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
Stephan Kellnberger and Georg Wissmeyer contributed equally.;2. Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA;3. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA;4. Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany Chair of Biological Imaging, Central Institute for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany |
| Abstract: | Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantial potential for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD. |
| Keywords: | intravascular endoscopy intravascular imaging intravascular ultrasound near-infrared imaging |