Ultrastructural and X-ray analytical studies on intranuclear bismuth inclusions |
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Authors: | F N Ghadially N K Yong |
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Institution: | 1. The Department of Pathology, University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
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Abstract: | Parenteral administration of bismuth subnitrate produced intranuclear inclusions in the rabbit kidney tubules. In glutaraldehyde fixed material these inclusions had a homogeneous appearance but in osmicated material some of these inclusions showed a granular and fibrillar substructure. In relatively thick unstained sections prepared from unosmicated tissues, it was found that the inclusions were electron-dense, but they vanished from view when the electron beam was focussed on them. This phenomenon is thought to be due to the presence of bismuth, which is a mental with a high electrical resistance and low thermal conductivity. With the aid of electron-probe analysis the presence of bismuth was demonstrated in these inclusions and it seems possible that sulphur may be present here. |
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