Interfacial bioconjugation on emulsion droplet for biosensors |
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| Authors: | Qifan Zhang Anita Scigliano Tarita Biver Andrea Pucci Timothy M Swager |
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| Institution: | 1. Department of Chemistry and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States;2. Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, I-56124 Pisa, Italy |
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| Abstract: | Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic acids and carbohydrates. |
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| Keywords: | Bioconjugation Biosensors Interfacial functionalization Emulsions Janus particles |
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