Synthesis and pharmacology of 1-methoxy analogs of CP-47,497 |
| |
| Authors: | John W Huffman Seon A Hepburn Patricia H Reggio Dow P Hurst Jenny L Wiley Billy R Martin |
| |
| Institution: | 1. Howard L. Hunter Laboratory, Clemson University, Clemson, SC 29634-0973, United States;2. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, United States;3. Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, United States |
| |
| Abstract: | Three 1-methoxy analogs of CP-47,497 (7, 8, and 19) have been synthesized and their affinities for the cannabinoid CB1 and CB2 receptors have been determined. Although these compounds exhibit selectivity for the CB2 receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of these compounds for either receptor. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
