Near-infrared-fluorescence imaging of lymph nodes by using liposomally formulated indocyanine green derivatives |
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| Institution: | 1. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China;2. School of Pharmacy, Binzhou Medical University, Yantai 264003, China;3. Key Laboratory of Structure-Based Drug Design, Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;4. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Liposomally formulated indocyanine green (LP-ICG) has drawn much attention as a highly sensitive near-infrared (NIR)-fluorescence probe for tumors or lymph nodes in vivo. We synthesized ICG derivatives tagged with alkyl chains (ICG-Cn), and we examined NIR-fluorescence imaging for lymph nodes in the lower extremities of mice by using liposomally formulated ICG-Cn (LP-ICG-Cn) as well as conventional liposomally formulated ICG (LP-ICG) and ICG. Analysis with a noninvasive preclinical NIR-fluorescence imaging system revealed that LP-ICG-Cn accumulates in only the popliteal lymph node 1 h after injection into the footpad, whereas LP-ICG and ICG accumulate in the popliteal lymph node and other organs like the liver. This result indicates that LP-ICG-Cn is a useful NIR-fluorescence probe for noninvasive in vivo bioimaging, especially for the sentinel lymph node. |
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| Keywords: | Liposome Indocyanine green (ICG) Near-infrared (NIR)-fluorescence probe Phospholipid Lymph node |
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