Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII |
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Authors: | Ramazan Ulus İbrahim Yeşildağ Muhammet Tanç Metin Bülbül Muharrem Kaya Claudiu T Supuran |
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Institution: | 1. Chemistry Department, Faculty of Arts and Science, Dumlup?nar University, 43100 Kütahya, Turkey;2. Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, 50019 Sesto Fiorentino (Florence), Italy |
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Abstract: | 4-Amino-N-(4-sulfamoylphenyl)benzamide was synthesized by reduction of 4-nitro-N-(4-sulfamoylphenyl)benzamide and used to synthesize novel acridine sulfonamide compounds, by a coupling reaction with cyclic-1,3-diketones and aromatic aldehydes. The new compounds were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), and more precisely the cytosolic isoforms hCA I, II and VII. hCA I was inhibited in the micromolar range by the new compounds (KIs of 0.16–9.64 μM) whereas hCA II and VII showed higher affinity for these compounds, with KIs in the range of 15–96 nM for hCA II, and of 4–498 nM for hCA VII. The structure–activity relationships for the inhibition of these isoforms with the acridine–sulfonamides reported here were also elucidated. |
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Keywords: | Carbonic anhydrase Acridine Sulfonamide Enzyme inhibition Isoforms CA I II and VII |
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