Microbial and reducing agents catalyze the rearrangement of taxanes |
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| Authors: | Sun D A Nikolakakis A Sauriol F Mamer O Zamir L O |
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| Institution: | Human Health Research Center, INRS-Institut Armand-Frappier, Université du Québec, 531 Boulevard des Prairies, Laval, H7V 1B7, Canada. |
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| Abstract: | 5alpha, 7beta, 9alpha, 10beta, 13alpha-Pentahydroxy-4(20),11(12)-taxadiene derivative 1 was converted to two unprecedented 1(15-->11)abeo-taxanes and a taxane derivative with a C10-C11 double bond by Absidia coerula ATCC 10738a. A similar compound was obtained from treatment with zinc of a triacetoxy-4(20),11(12)-taxadiene derivative. |
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