Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics |
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Authors: | Milo? Erak Kathrin Bellmann-Sickert Sylvia Els-Heindl Annette G Beck-Sickinger |
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Institution: | Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Bruederstrasse 34, 04103 Leipzig, Germany |
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Abstract: | The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic strategies in order to improve peptidic properties, such as longer half-life, higher bioavailability, increased potency and efficiency is accordingly rising. In this mini-review, we present a toolbox of modifications in peptide chemistry for overcoming the main drawbacks during the transition from natural peptides to peptide therapeutics. Modifications at the level of the peptide backbone, amino acid side chains and higher orders of structures are described. Furthermore, we are discussing the future of peptide therapeutics development and their impact on the pharmaceutical market. |
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Keywords: | Peptide therapeutics Peptide synthesis Peptide modifications Lipidation PEGylation |
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