Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity |
| |
| Authors: | Hao Zhang Xuejian Wang Jing Mao Yongxue Huang Wenfang Xu Yu Duan Jian Zhang |
| |
| Institution: | 1. Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, Shandong 261053, PR China;2. Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, Shandong 261053, PR China;3. Weifang Bochuang International Biological Medicinal Institute, Weifang, Shandong, 261061, PR China;4. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong 250012, PR China |
| |
| Abstract: | On the basis of the strategy of “multifunctional drugs”, a series of novel matrix metalloproteinase inhibitors (MMPIs) containing benzofuroxan scaffold as a nitric oxide donor were designed, synthesized and evaluated. All synthesized compounds, especially 16a, exhibited potent MMP-2,9 inhibitory activities, anti-proliferative activities and could produce high levels of NO in Hela cells. They were also evaluated for both of their anti-invasion and anti-angiogenesis effects. Furthermore, compared with LY52, 16a demonstrated competitive antitumor activity in vivo. These hybrid NO-MMPIs might offer suitable scaffolds to develop valuable MMP inhibitors for the further discovery of novel anti-cancer drugs. |
| |
| Keywords: | MMP inhibitor Nitric oxide Benzofuroxan Multifunctional drugs Synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
