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3-hydroxy fatty acids found in capsules of Cryptococcus neoformans
Authors:Sebolai Olihile M  Pohl Carolina H  Botes Piet J  Strauss Catharina J  van Wyk Pieter W J  Botha Alfred  Kock Johan L F
Institution:UNESCO MIRCEN: Industrial Biotechnology, Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, P.O. Box 339, Bloemfontein, South Africa.
Abstract:Using immunofluorescence confocal laser scanning microscopy, immunogold transmission electron microscopy and gas chromatography--mass spectrometry, we demonstrated the presence of 3-hydroxy fatty acids in Cryptococcus neoformans. Our results suggest that these oxylipins accumulate in capsules where they are released as hydrophobic droplets through tubular protuberances into the surrounding medium.
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