Preliminary crystallographic study of macromomycin: The apoprotein of the antitumor antibiotic auromomycin |
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Authors: | Patrick Van Roey Charles M Weeks FE DeJarnette Terry A Beerman Mary McHugh |
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Institution: | Medical Foundation of Buffalo, Inc. 73 High Street, Buffalo, NY 14203, U.S.A.;Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, NY 14263, U.S.A. |
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Abstract: | Macromomycin (Mr 12,000) is the apoprotein of the antitumor drug auromomycin, which inhibits DNA synthesis by causing single-strand breaks in DNA. Two orthorhombic crystal forms of macromomycin have been observed. The platelike crystals of one form belong to space group P212121, with cell dimensions . The crystals of the second form are needle-shaped, and belong to space group P21212, with cell dimensions . At this point in time, the platelike crystals appear the most suitable for continued crystallographic studies. |
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