Preliminary X-ray crystallographic analysis of a modified basic fibroblast growth factor |
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| Authors: | D M Bollag A P Seddon P B?hlen Y Gluzman C E Schutt |
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| Institution: | Department of Chemistry, Princeton University, NJ 08544. |
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| Abstract: | Human basic fibroblast growth factor (hbFGF) has been modified, with Ala3 and Ser5 substituted by glutamic acid, and the purified recombinant protein has been crystallized. The crystals are triclinic (space group P1) with unit cell parameters a = 31.0 A, b = 33.6 A, c = 34.7 A, alpha = 88 degrees, beta = 85 degrees, gamma = 76 degrees, and they diffract to at least 2 A. |
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