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Identification of Novel Alternative Splicing Events in the Huntingtin Gene and Assessment of the Functional Consequences Using Structural Protein Homology Modelling |
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| Authors: | Alis C Hughes Matthew Mort Lyn Elliston Rhian M Thomas Simon P Brooks Stephen B Dunnett Lesley Jones |
| Institution: | 1 Institute of Psychological Medicine and Clinical Neuroscience, MRC Centre for Neuropsychiatric Genetics and Genomics, Hadyn Ellis Building, Cardiff University, Cardiff CF24 4HQ, UK;2 Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK;3 Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK |
| Abstract: | |
| Keywords: | HD Huntington's disease UTR untranslated region PTC premature termination codon qPCR quantitative PCR 3D three-dimensional PDB Protein Data Bank GO Gene Ontology TNPO1 Transportin 1 MSA multiple sequence alignment |
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