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Structure and Cleavage Specificity of the Chymotrypsin-Like Serine Protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) |
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| Authors: | Xinsheng Tian Guangwen Lu Feng Gao Hao Peng Guangpeng Ma Mark Bartlam Jinghua Yan George F Gao |
| Institution: | 1 CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China 2 Graduate University, Chinese Academy of Sciences, Beijing 100049, China 3 College of Life Science, China Agricultural University, Beijing 100094, China 4 Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China 5 College of Life Sciences and Tianjin Key Laboratory of Protein Science, Nankai University, Tianjin 300071, China 6 China Animal Disease Control Center, Beijing 100094, China 7 Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany 8 China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China 9 Beijing Institutes of Life Science, Chinese Academy of Sciences, Lincui East Road, Beijing 100101, China |
| Abstract: | |
| Keywords: | nsp nonstructural protein 3CLSP 3C-like serine protease EAV equine arteritis virus SARS-CoV severe acute respiratory syndrome coronavirus 3CLpro 3C-like proteinase GST glutathione S-transferase MR molecular replacement SeMet selenomethionine PDB Protein Data Bank SGPE Streptomyces griseus proteinase E MS mass spectrometry MW molecular weight ESI electrospray ionization |
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