| 人类短串联重复序列HUMTH01基因座的遗传多态性 |
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| 引用本文： | 侯一平 Staa,M.人类短串联重复序列HUMTH01基因座的遗传多态性[J].遗传学报,1996,23(3):174-182. |
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| 作者姓名： | 侯一平 Staa M |
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| 作者单位： | 华西医科大学法医学系 |
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| 基金项目： | 国家自然科学基金,卫生部青年科技人才专项基金 |
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| 摘 要： | 作者用扩增片段长度多态技术分析了人类短串联重复序列ＨＵＭＴＨ０１基因型及等位基因频率在中国成都地区汉族群体和德国科隆地区白人中的分布。用同步电泳技术比较不同引物ＰＣＲ产物分型结果，评估不同实验室ＨＵＭＴＨ０１群体数据的可比性。计算了２５个群体间ＨＵＭＴＨ０１ＳＴＲ的遗传距离，并构建了系统树。ＨＵＭＴＨ０１ＳＴＲ系统树分析不仅与传统遗传标记结果一致，并且获得了群体遗传的新线索。
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| 关 键 词： | 群体遗传学，短串联重复序列，遗传距离，HUMTH01基因座，系统树，聚合酶链式反应 |
Population Genetics of Short Tandem Repeat Locus HUMTH01 |
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| Hou Yiping,Gou Qing,Wu Meiyun.Population Genetics of Short Tandem Repeat Locus HUMTH01[J].Journal of Genetics and Genomics,1996,23(3):174-182. |
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| Authors: | Hou Yiping Gou Qing Wu Meiyun |
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| Abstract: | The distributions of genotypes and allele frequencies for the short tandem repeat locus HUMTH01 in Chinese and German populations were studied by amplified fragment length polymorphism analysis.The PCR amplification products with different primers were compared by coelectrophoresis and the population data from different laboratories were evaluated. Based on the allele frequencies of HUMTH01,the genetic distances among 25 populations were computed and a phylogenetic tree was constructed accordingly.Some new implications for population genetics were obtained from this phylogenetic tree. |
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| Keywords: | Population genetics HUMTH01 Short tandem repeats Polymerase chain reaction Genetic distance Phylogenetic tree |
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