| 三种有丝分裂抑制剂诱发小鼠骨髓细胞非整倍体的比较研究 |
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| 引用本文： | 汪旭,B.Miller,U.Kliesch,I.D.Adler.三种有丝分裂抑制剂诱发小鼠骨髓细胞非整倍体的比较研究[J].遗传学报,1991(4). |
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| 作者姓名： | 汪旭 B.Miller U.Kliesch I.D.Adler |
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| 作者单位： | 云南师范大学生物系，德意志联邦共和国环境及辐射研究中心(GSF)遗传学研究所，德意志联邦共和国环境及辐射研究中心(GSF)遗传学研究所，德意志联邦共和国环境及辐射研究中心(GSF)遗传学研究所 昆明 650092，慕尼黑、德意志联邦共和国，慕尼黑、德意志联邦共和国，慕尼黑、德意志联邦共和国 |
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| 基金项目： | 欧洲经济共同体(EEC)提供资助 |
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| 摘 要： | 以秋水仙素有丝分裂(CM)效应、微核(MN)及染色体畸变(CA)三种体内细胞遗传学指标综合评估了有丝分裂抑制剂(秋水仙素、益康唑及对苯二酚)诱发小鼠骨髓细胞非整倍体的效应。结果表明:秋水仙素是典型的多倍体及非整倍体诱发剂。益康唑对细胞有丝分裂有与秋水仙素相类似的效应,进一步分析表明其在哺乳动物体细胞内无非整倍体诱发效应。对苯二酚在哺乳动物活体实验系统中,可能具有诱发非整倍体及染色体结构畸变的多种遗传毒性。结果提示三种细胞遗传学指标能为非整倍体诱发剂的检出提供依据。
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| 关 键 词： | 秋水仙素有丝分裂 非整倍体 微核 染色体畸变 有丝分裂抑制剂 骨髓细胞 |
A Study of Aneuploid Induction by Three Mitotic Arrestants in Mouse Bone Marrow Cells |
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| Wang Xu.A Study of Aneuploid Induction by Three Mitotic Arrestants in Mouse Bone Marrow Cells[J].Journal of Genetics and Genomics,1991(4). |
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| Authors: | Wang Xu |
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| Abstract: | Three mitotic arrestants, i.e., colchcine(COL), eeonazole(EZ) and hydroquinone (HQ) have been assayed by means of C-Mitocic(CM) effects, micronucleus (MN) and chromosomal aberration (CA) test for their effects of aneuploid induction in mouse bone marrow cells COL induced poly/aneuploid in mouse bone marrow cells. EZ was weakly positive in CM effects test but it may not induce aneuploid in mammalian cells. HQ could not only be a cla-stogen but also an aneuploid inducer. The results indicated that the comparative employment of the three cytogenetic criteria could be quite useful for detecting aneuploidy inducers in mammalian somatic cells in vivo. |
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| Keywords: | Colchcine mitosis Aneuploid Micronuclcus Chromotomal aberration Mitotic arrestant Bone marrow cell |
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