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HbD-Punjab 85例在新疆的分布及其起源问题的讨论
引用本文:李厚钧,刘德祥,李力,刘志国,赵军,韩小鹏,余伍忠.HbD-Punjab 85例在新疆的分布及其起源问题的讨论[J].遗传学报,1987(3).
作者姓名:李厚钧  刘德祥  李力  刘志国  赵军  韩小鹏  余伍忠
作者单位:乌鲁木齐军区总医院遗传室,乌鲁木齐军区总医院遗传室,乌鲁木齐军区总医院遗传室,乌鲁木齐军区总医院遗传室,中国人民解放军第23医院,中国人民解放军第13医院,中国人民解放军第273医院 新疆,新疆,新疆,新疆
摘    要:对新疆21个民族140,433人进行了异常血红蛋白普查,检出575例,随机抽样153例进行结构分析,其中85例为HbD-Punjab,证实新疆异常Hb以HbD-Punjab为最多,占55.6%。并以维吾尔族为代表,对新疆中南部、北部及西南部的发生率进行比较,说明HbD-Punjab基因在新疆不存在由西南向北部或北部向西南漂移的趋势。文章结合我国蒙古族与欧亚几个国家HbD-Punjab发生率及分布特点的比较,认为英国学者Lehmann提出的HbD-Puajab基因起源蒙古族的假说不能成立,提出HbD-Punjab基因不是起源于蒙古族,而可能源于中亚地区的新见解。

关 键 词:异常血红蛋白  血红蛋白旁遮普  结构分析

Discussion on Origin of HbD-Punjab and Its Distribution in Xinjiang
Li Houjun Liu Dexiang Li Li Liu Zhiguo Zhao Jun Han Xiaopen Yu Wuzhong.Discussion on Origin of HbD-Punjab and Its Distribution in Xinjiang[J].Journal of Genetics and Genomics,1987(3).
Authors:Li Houjun Liu Dexiang Li Li Liu Zhiguo Zhao Jun Han Xiaopen Yu Wuzhong
Abstract:140,433 persons of 21 nationalities were surveyed for the presence of abnormal hemoglobin.The structural analyses of 153 cases were performed out of a total of 575 cases found,and 85 cases were recognized as HbD-Puniab.This varient is most common in Xinjiang (The incidence 55.6%).Taking Uygur nation as an example,comparing the incidence of HbD-Punjab-in the southwest,bordering India Subcontinent and Central Asia,as well as south,middle and north region of Xinjiang,it shows that HbD-Punjab gene does not drift from the southwest to-north or in the opposite direction.Analyses of HbD-Punjab incidence and distribution feature in Mongolia ethnic group and several other Asia and European countries seem to disprove Lehmann's hypothesis that HbD-Punjab gene was originated from Mongolia nationality.Our results suggest that HbD-Punjab gene originates from Middle Asia.
Keywords:Abnormal hemoglobin  HbD-Punjab  Structure analysis
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