塔克拉玛干沙漠腹地隔离人群线粒体DNA序列多态性分析

对新疆塔克拉玛干沙漠腹地的75名克里雅人线粒体DNA的高可变I区的15996—16401的片段进行了序列分析，在所测定的75个个体中，共检测到68个位点存在变异，界定了71种不同的单倍型。克里雅人群的核昔酸变异度和平均核苷酸差异都介于所报道的东方人群和西方人群之间。根据Neighbor-joining法构建系统发育树，发现中亚的各人群均处于东方人群的亚洲谱系和西方人群的欧洲谱系之间，并且克里雅与新疆维吾尔和境外维吾尔之间的遗传距离最近，表明他们之间有很密切的亲缘关系。

Mitochondrial DNA Sequence Variations of Keriyan in the Taklamakan Desert

The Keriyans live in the center of the Taklamakan desert of Xinjiang Province and they have never married with outsiders.Nobody knows clearly how they immigrated here and who was their origin.The mtDNA hypervariable segment I sequences were sequenced in 75 Keriyans.Seventy-one unique HVS I types were identified,varing at 68 nucleotide positions.Nucleotide diversity and the mean pairwise differences of Keriyan are intermediate between those reported for Eastern and Western populations. Keriyan's low Tajima's D statistics and bell-shaped pairwise-difference distributions can be interpreted as the hallmark of an ancient population expansion.Phylogenetic analysis shows Central Asian populations occupy a position intermediate between the Eastern and Western populations,moreover,the Keriyan presents shorter genetic distances to Xinjiang Uighur and Uighur in other places than to other populations.