中国汉族人群(西安)STR基因扫描与遗传结构

选择9种STR基因位点和Amelogenin基因位点,以测序为基础,研究我国汉族人群STR遗传结构.采用基因自动测序仪建立了10个位点基因分析方法,通过对汉族群体的基因扫描、基因分型和遗传结构分析,获得了STR基因传递特征的大量基因遗传数据,在汉族人群DP为1.05×10-0,EPP为0.9998,为建立我国不同民族STR基因数据库、基因资源研究与保护奠定了基础,为生物考古、基因诊断、性别鉴定、个人识别,司法审判、侦察破案提供有力的科学依据.

Genescan for STR Analysis and Genetic Distribution in a Population Sample from Han China

Genetic distributions for nine STR loci and Amelogenin locus weredetermined in a Chinese Han population based on DNA sequencing. The databanks inChnese Population were generated by using Genescan, genotype and geneticdistribution analysis. Allele frequentcy distribution was determined for 10 loci, such asD3S1358, VWA, FGA, Amelogenin, IHO1, TPOX CSF1PO, D5S818, D13S317 andD7S820. The results show significant differences between ethnic groups (AfricanAmerican, US-Cauasian and Chinese Han) in the pattern of distribution as well as inthe related frequency of the most common alleles of their STR loci. The probabilitiesof identity values for the population described in this section are 2.79 X 10-10 (U.SCaucasian), 1.23 X 10- 10 (African-American and 0.5 x 10- 10 (Chinese Han) Theresults show the probability of Paternity Exclusion (PPE) values of 0.9998 (ChineseHan, 0.9996 (African-American) and 0.9994 (U.S-Caucasian). These results suggestedthat the nine STR loci and the Amelogenin locus are very useful for humanidentification, such as analyzing forensis casework, establishing DNA databanks,processing paternity test evaluation linkage genetics, studying gene natural resourcesand monitoring bone marrow transplants