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转基因植物疫苗的研究进展
引用本文:韩梅,苏涛,祖元刚,安志刚.转基因植物疫苗的研究进展[J].遗传学报,2006,33(4):285-293.
作者姓名:韩梅  苏涛  祖元刚  安志刚
作者单位:1. 东北林业大学森林植物生态学教育部重点实验室,哈尔滨,150040
2. 东北林业大学生命科学学院,哈尔滨,150040
摘    要:近些年,随着遗传技术和植物基因工程的发展进步,疫苗(亚单位疫苗、活载体疫苗和核酸疫苗等)的研究迅速发展起来。尤其是利用转基因植物技术生产植物疫苗的研究受到了广泛的关注,在转基因植物(蔬菜、水果、农作物)的可食用部位表达抗原生产人或动物治疗用重组蛋白和疫苗的技术为可食性疫苗的研制开辟了新途径,展现了诱人的开发前景。植物来源的疫苗具有很多优势,如生产成本低、易于保存、免疫接种方便、甚至不需提取纯化等处理而直接食用。目前已有很多转基因植物疫苗产品投入开发和生产。文章综述了近几年转基因植物疫苗在表达系统、生产、生物安全/管理、公众健康等方面的研究进展,对转基因植物疫苗存在的问题进行了分析,并对其研究前景提出了展望。

关 键 词:植物疫苗  重组蛋白  转基因植物疫苗  生物安全
收稿时间:2005-09-07
修稿时间:2005-09-072005-10-13

Research Advances on Transgenic Plant Vaccines
HAN Mei,SU Tao,ZU Yuan-Gang,AN Zhi-Gang.Research Advances on Transgenic Plant Vaccines[J].Journal of Genetics and Genomics,2006,33(4):285-293.
Authors:HAN Mei  SU Tao  ZU Yuan-Gang  AN Zhi-Gang
Institution:1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China ;2. Institute of Life Sciences, Northeast Forestry University, Harbin 150040, China
Abstract:In recent years, with the development of genetics molecular biology and plant biotechnology, the vaccination (e.g. ge-netic engineering subunit vaccine, living vector vaccine, nucleic acid vaccine) programs are taking on a prosperous evolvement. In particular, the technology of the use of transgenic plants to produce human or animal therapeutic vaccines receives increasing atten-tion. Expressing vaccine candidates in vegetables and fruits open up a new avenue for producing oral/edible vaccines. Transgenic plant vaccine disquisitions exhibit a tempting latent exploiting foreground. There are a lot of advantages for transgenic plant vac-cines, such as low cost, easiness of storage, and convenient immune-inoculation. Some productions converged in edible tissues, so they can be consumed directly without isolation and purification. Up to now, many transgenic plant vaccine productions have been investigated and developed. In this review, recent advances on plant-derived recombinant protein expression systems, infectious targets, and delivery systems are presented. Some issues of high concern such as biosafety and public health are also discussed. Special attention is given to the prospects and limitations on transgenic plant vaccines.
Keywords:plant-based vaccines  recombinant proteins  transgenic plant vaccines  biosafety
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