| 人类复杂遗传疾病QTL分析方法的理论探讨 |
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| 引用本文： | 胡中立,董卫国,宋运淳.人类复杂遗传疾病QTL分析方法的理论探讨[J].遗传学报,2002,29(2):101-104. |
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| 作者姓名： | 胡中立 董卫国 宋运淳 |
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| 作者单位： | 1. 武汉大学生命科学学院发育生物学教育部重点实验室,武汉,430072
2. 武汉大学医学院,武汉,430064 |
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| 摘 要： | 利用连锁不平衡理论，人类遗传学家已能把影响人类疾病的质量基因定位在小至1cM区域内，有些基因已被克隆出来。罗泽伟等进一步发展统计分析方法检测及估算分子标记与QTL之间的连锁不平衡系数，从而提出了人类复杂遗传病高解析度基因定位的理论策略。以此为基础，进一步探讨了供试群体在双亲基因频率存在差异时检测QTL和检测QTL互作的方法，给出了有关的理论结果。
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| 关 键 词： | 复杂遗传病 连锁不平衡 基因定位 QTL分析 |
| 文章编号： | 0379-4172(2002)02-0101-04 |
| 修稿时间： | 2000年12月22 |
Theoretical Studies of QTL Analysis of Complex Genetic Diseases in Humans |
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| Abstract: | Some genes controlling human diseases have been located on the regions less than 1 cM using linkage disequilibrium, and a few of them have been cloned. Z. W. Luo developed a method that can detect and estimate the coefficient of linkage disequilibrium between a marker locus and quantitative trait locus (QTL), and raised the theoretical strategies for high resolution mapping of complex genetic disorders in humans. Based on the data mentioned above, a method for linkage test between a marker locus and QTL was set up, and a method for linkage test between two marker loci and epistatic QTL was suggested for the first time. |
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| Keywords: | complex genetic diseases linkage disequilibrium gene mapping QTL analysis |
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