| 减毒麻疹活疫苗对小鼠的细胞遗传学效应 |
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| 引用本文： | 史庆华,施立明.减毒麻疹活疫苗对小鼠的细胞遗传学效应[J].遗传学报,1990,17(4):269-275. |
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| 作者姓名： | 史庆华 施立明 |
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| 作者单位： | 中国科学院昆明动物研究所，中国科学院昆明动物研究所 安徽省职业病防治研究所 |
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| 摘 要： | 本文以C57BL/6J小鼠为材料,以骨髓细胞微核、染色体畸变和生殖细胞微核、染色体畸变为指标,对国产减毒麻疹活疫苗的遗传安全性进行评价。结果表明,麻疹疫苗可引起小鼠骨髓微核细胞率、染色体畸变率以及精细胞微核细胞率明显升高,与接种剂量和接种后的时间有关;生殖细胞染色体畸变和对照比无显著性差异。
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| 关 键 词： | 麻疹疫苗 小鼠 染色体畸变 微核 |
Cytogenetic Effects of Attenuated Live Measles Vaccine on Male Mice |
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| Shi Qinghua Shi Liming.Cytogenetic Effects of Attenuated Live Measles Vaccine on Male Mice[J].Journal of Genetics and Genomics,1990,17(4):269-275. |
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| Authors: | Shi Qinghua Shi Liming |
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| Abstract: | The cytogenetic effects of attenuated live measles vaccine on somatic and germinal cells of C57BL/6J mice were studied. The frequencies of micronuclei of polychromatic erythrocytes, nucleated cells, chromatid breaks, fragments in bone marrow cells, and micronuclei of spermatids in testes were increased, which have dose- and time-dependent relationship. However, there were no statistical difference between the treated and control mice in chromosomal breaks and fragments of spermatogonia primary and secondary spermatocytes. The results and their possible biological significance were also discussed. |
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| Keywords: | Measles vaccine Mice Microhuclei Chromosomal aberrations |
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