桉属植物非挥发性化学成分和药理活性研究进展

桉属(Eucalyptus L. Herit)是桃金娘科(Myrtaceae)的大属，该属约600余种，主要分布于世界各地热带亚热带地区。我国引入品种较多，主要分布于华南地区，其中广东和广西为桉树的主要种植基地。桉属植物具有较多的工业价值，其木材、叶、果实等是化学工业、香料、医药领域的重要原料，可用作开发高性能桉木重组材、竹桉复合材料、造浆与造纸等。桉属植物作为民间药材被使用，具有抑菌消炎、疏风解热、防腐止痒等功效，其药理研究表明，桉属植物具有良好的抗氧化、抗炎、抗菌、抗病毒、抗肿瘤、抗心血管疾病等药理活性。该研究通过查阅近三十年桉属植物相关的国内外文献报道，对桉属植物不同部位的421个非挥发性化学成分及其药理活性等进行了较详细的分类阐述，其中黄酮类化合物共73个、有机酸化合物共61个、萜类化合物共45个、多酚类化合物共229个、脂肪醇类化合物共13个，药理活性多集中在抗氧化、抗菌、抗病毒、抗肿瘤等，但相关机制仍需进一步阐明。该文重点关注桉属植物的药用部位，充分发掘其药用价值，开展临床转化和新药研究工作，为今后桉属植物的进一步研究、开发和利用提供科学依据。

Research progress of non-volatile chemical components from Eucalyptus genus plants and their pharmacological activities

Eucalyptus L. Herit is a large genus of Myrtaceae with more than 600 species, native to Australia and some of its northern islands and mainly distributed in tropical and subtropical regions of the world. Eucalyptus has the characteristics of fast growth, high yield, short rotation period and so on. It is an excellent pulp material with remarkable economic benefits. There are many introduced species in China, mainly distributed in South China. Nearly 80 species have been introduced into China since 1890, and are widely distributed in Guangdong, Guangxi, Guizhou, Sichuan, Yunnan, Jiangxi and other places. At present, China has become one of the countries with the largest area of Eucalyptus plants in the world and is also the largest exporter of Eucalyptus oil. Eucalyptus has a lot of industrial value. Its wood, leaves and fruits are important raw materials in chemical industry, fragrance and medicine fields. They can be used for developing high performance Eucalyptus recombination material, bamboo Eucalyptus composite material, pulp and paper-making, etc. Eucalyptus plants are used as folk medicine, with anti-bacterial and anti-inflammatory, wind-relieving and anti-pyretic, anti-corrosion and anti-pruritic effects. As a traditional medicine, Australian aborigines are the first to use Eucalyptus for the treatment of fever and bronchial diseases; in China, the leaves of E. globulus, E. robusta, E. exserta, E. tereticornis, E. citriodora are often used to treat influenza, dysentery, eczema, and injuries for a long time. Pharmacological studies show that Eucalyptus plants have good anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-tumor, anti-cardiovascular diseases and other pharmacological activities. In this study, 421 non-volatile chemical constituents from different parts of Eucalyptus and their pharmacological activities are classified and described in detail by referring to the domestic and foreign literatures related to Eucalyptus in recent 30 years. There are 73 flavonoids, 61 organic acids, 45 terpenoids, 229 polyphenols and 13 fatty alcohols. Most of the pharmacological activities are anti-oxidant, anti-bacterial, anti-viral and anti-tumor, but the related mechanisms still need to be further elucidated. This study focuses on the medicinal parts of Eucalyptus, fully explores their medicinal value, and carries out clinical transformation and new drug research, which provides scientific basis for further research, development and utilization of Eucalyptus in the future.