Effects of cysteamine on pro-somatostatin related peptides |
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| Authors: | C Bakhit R Benoit F E Bloom |
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| Institution: | 1. A.V. Davis Center for Behavioral Neurobiology, The Salk Institute, La Jolla, CA 92037, U.S.A.;2. Laboratories for Neuroendocrinology, The Salk Institute, La Jolla, CA 92037, U.S.A. |
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| Abstract: | Intracerebroventricular (icv) injection of cysteamine to rats produced a marked depletion of somatostatin-14-like immunoreactivity (LI) in all rat brain regions examined. The somatostatin-28 (SS28)-LI and SS28(1-12)-LI were generally not altered by the cysteamine treatment. Following subcutaneous injection of the drug similar depletions of hypothalamic SS14-LI was observed with no change in SS28-LI nor SS28(1-12)-LI. In vitro cysteamine significantly increased the basal release of SS14-LI and markedly potentiated the evoked release of SS14-LI from hypothalamic slices. At 10 mM cysteamine, enhanced release of SS14-LI from hypothalamic slices was still observed despite a marked depletion of tissue content of SS14-LI. |
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| Keywords: | somatostatin cysteamine brain regions release |
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