肠道微生物菌群对脑及行为的影响

肠道微生物菌群组成的变化对正常生理的影响及其在疾病中的作用逐渐成为研究热点。肠道微生物菌群通过脑肠轴影响宿主生理学的各个方面,包括脑-肠交流、脑功能甚至行为。对无菌动物、被致病细菌感染的、使用益生菌或用抗生素药物的动物研究表明,肠道微生物菌群可以调节宿主焦虑样症状及行为。研究表明对肠道微生物菌群的调节可能是治疗复杂中枢神经系统失调症的新策略。

Effects of gut microbiota on brain and behavior

The influence of the composition of gut microbiota on normal physiology and diseases has beenbecoming major research interests in recent years. The gut microbiota has significantly influenced all aspectsof physiology, including gut-brain communication, brain function and even behavior through the gut-brainaxis. Studies on the germ-free animals, animals infected with pathogenic bacteria and those exposed to probi-otic agents or antibiotics suggest a role of the gut microbiota in modulating anxiety and depress-like behavior.Most of the studies have suggested that modulation of the gut microbiota may be a strategy for developingnovel therapeutics for complex disorders of central nervous system.