细胞内吞的研究进展

细胞外基质的各种分子经细胞膜进入真核细胞是一个复杂的过程。细胞内吞是通过细胞质膜的变形运动将细胞外物质转运入细胞内的过程。不同的细胞内吞途径需要不同的蛋白质分子参与,引起不同的信号转导通路。目前认为细胞内吞和膜转运是细胞对其信号转导过程的一种精密的组织安排,细胞内吞在细胞信号转导,维持机体动态平衡方面起着重要作用。细胞内吞途径通常可以分为网格蛋白依赖的内吞和非网格蛋白依赖的内吞,其中后者包括陷窝蛋白依赖和非陷窝蛋白依赖的内吞,以及巨胞饮介导的内吞。本文将就这几种主要细胞内吞途径及与细胞信号转导通路关系的研究进展予以介绍。

Research progress of cell endocytosis

It is a complex process for the movement of multiple extracellular matrix molecules crossingthe eukaryotic cell membrane. Endocytosis is such a process, through which extracellular materials can betransported across the membrane. Different endocytosisfactors, which can activate different signaling pathwayspathways require the participation of diverse proteinCurrently, endocytosis and membrane trafficking areconsidered to be precise and highly organized in cellular signaling transduction system. In addition, endocytosisplays key roles in cellular signaling and homeostasis. In general, endocytosis can be divided into two types：the clathrin-dependent and clathrin-independent endocytosis pathways. The clathrin-independent endocytosispathways could be subdivided into three categories： caveolin-dependent endocytosis, caveolin-independentendocytosis and macropinocytosis. In this review, we will outline the research advance in the relationship be-tween the main endocytosis pathways and cell signaling transduction.