| 血浆游离DNA检测在心血管系统疾病诊断中的应用 |
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| 引用本文： | 何鑫,张青海,唐毅,郑昭芬.血浆游离DNA检测在心血管系统疾病诊断中的应用[J].生命的化学,2021(1):68-76. |
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| 作者姓名： | 何鑫 张青海 唐毅 郑昭芬 |
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| 作者单位： | 湖南师范大学附属第一医院/湖南省人民医院心血管内科 |
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| 基金项目： | 湖南省社会发展领域重点研发项目(2019SK2021);国家自然科学基金青年科学基金项目(81800056)。 |
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| 摘 要： | 心血管疾病发病率和病死率居高不下,寻求敏感性高的生物学指标帮助早期诊断和改善预后意义重大。血浆游离DNA(cell-free DNA, cfDNA)是一类存在于血浆、尿液及其他体液中游离于细胞之外的双链DNA片段。血浆cfDNA水平在心血管疾病的早期明显升高,提示其可能是心血管疾病的潜在生物标志物。为了更深入理解cfDNA在心血管疾病中的研究进展,本文就cfDNA的生物学特性、在心血管疾病中的作用和应用进展进行了总结。
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| 关 键 词： | 血浆游离DNA 心血管疾病 预后 生物标志物 |
Application of cell-free DNA in the diagnosis of cardiovascular diseases |
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| HE Xin,ZHANG Qinghai,TANG Yi,ZHENG Zhaofen.Application of cell-free DNA in the diagnosis of cardiovascular diseases[J].Chemistry of Life,2021(1):68-76. |
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| Authors: | HE Xin ZHANG Qinghai TANG Yi ZHENG Zhaofen |
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| Institution: | (Department of Cardiology,the First Affiliated Hospital of Hunan Normal University/Hunan Provincial People's Hospital,Changsha 410000,China) |
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| Abstract: | It is considerable to seek new biomarkers with high sensitivity for early diagnosis due to high morbidity and mortality of cardiovascular diseases. Plasma cell free DNA(cfDNA) is a type of doublestranded DNA fragment existed in plasma, urine and other body fluids. Plasma cfDNA level is increased in the early stage of cardiovascular disease and suggest it may be a potential biomarker for cardiovascular disease. In this review, we summarized the biological characteristics of cfDNA, its biological roles and applications in cardiovascular diseases for a profound understanding and perspective on the clinical significance of cfDNA in cardiovascular diseases. |
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| Keywords: | cfDNA cardiovascular disease prognosis biomarkers |
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