| 肠脑轴参与动物食欲的调节机制 |
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| 引用本文： | 龚雪娜,贾婷,张浩,王政昆,朱万龙.肠脑轴参与动物食欲的调节机制[J].生命的化学,2021(1):61-67. |
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| 作者姓名： | 龚雪娜 贾婷 张浩 王政昆 朱万龙 |
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| 作者单位： | 云南省高校西南山地生态系统动植物生态适应进化及保护重点实验室;云南医药健康学院 |
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| 基金项目： | 国家自然科学基金项目(31760118);云南省中青年学术和技术带头人后备人才项目(2019HB013);云南医药健康学院科学研究项目(2020Y002)。 |
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| 摘 要： | 肠脑轴是由中枢系统、胃肠道系统共同构成的双向通信系统,其主要通过下丘脑食欲中枢和胃肠道食欲激素来调节动物的食欲,控制其体重,参与能量稳态的调节,是研究动物肥胖和2型糖尿病等代谢疾病的重要轴系。本文综述了肠脑轴对动物食欲、能量平衡和体重的调节作用,展望了肠脑轴在肥胖等相关代谢疾病治疗中的研究前景。
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| 关 键 词： | 食欲 肥胖 肠脑轴 调节机制 |
The mechanism of gut-brain axis in appetite regulation in animals |
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| GONG Xuena,JIA Ting,ZHANG Hao,WANG Zhengkun,ZHU Wanlong.The mechanism of gut-brain axis in appetite regulation in animals[J].Chemistry of Life,2021(1):61-67. |
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| Authors: | GONG Xuena JIA Ting ZHANG Hao WANG Zhengkun ZHU Wanlong |
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| Institution: | (Key Laboratory of Ecological Adaptive Evolution and Conservation on Animals-Plants in Southwest Mountain Ecosystem of Yunnan Province Higher Institutes College,School of Life Sciences,Yunnan Normal University,Engineering Research Center of Sustinable Development and Utilization of Biomass Energy Ministry of Education,Key Laboratory of Yunnan Province for Biomass Energy and Environment Biotechnology,Kunming 650500,China;Yunnan Medical Health College,Kunming 650106,China) |
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| Abstract: | Gut-brain axis(GBA) was composed of central nervous system and gastrointestinal system common two-way communication system, which regulated appetite and weight control, participated in regulation of energy steady state through the hypothalamus appetite center, gastrointestinal appetite hormones. It is an important shafting to study metabolic diseases such as obesity and type 2 diabetes in animals. This review discussed the effects of the gut-brain axis on appetite, energy balance and body mass in mammals, research prospect of the gut-brain axis in the treatment of obesity and other related metabolic diseases is prospected. |
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| Keywords: | appetite obesity gut-brain axis regulatory mechanisms |
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